2. NF-κB Autophagy Cell Cycle/DNA Damage Epigenetics Apoptosis Anti-infection
  3. IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
  4. Resveratrol

Resveratrol  (Synonyms: 白藜芦醇; trans-Resveratrol; SRT501)

目录号: HY-16561 纯度: 99.94%
COA 产品使用指南

摩尔计算器

Resveratrol (trans-Resveratrol; SRT501) 是一种天然多酚，具有抗氧化，抗炎，保护心脏和抗癌的特性。 它的靶点广泛，如 mTOR、JAK、β-amyloid、Adenylyl cyclase、IKKβ、DNA polymerase。Resveratrol 也是一种特异性的 SIRT1 活化剂。Resveratrol 是有效的孕烷 X 受体 (PXR) 抑制剂。Resveratrol 是一种 Nrf2 激活剂，在小鼠模型中可以改善衰老相关的进行性肾损伤。Resveratrol 作用于内皮细胞促进 NO 产生。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Resveratrol Chemical Structure

Resveratrol Chemical Structure

CAS No. : 501-36-0

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥550
In-stock
200 mg ￥500
In-stock
500 mg ￥1050
In-stock
1 g   询价  
5 g   询价  

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Customer Review

Other Forms of Resveratrol:

Resveratrol 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 95 篇科研文献

WB
IF

    Resveratrol purchased from MCE. Usage Cited in: Redox Biol. 2022 Jun;52:102310.  [Abstract]

    Primary cardiomyocytes are transfected with NC-siRNA or Sesn2-siRNA for 24 h, and then treated with DOX (1 μM) in the presence or absence of Resveratrol (RES) (20 μM) for 24 h. Representative images of DHE (red) staining and quantification of the corresponding fluorescence intensity in H9c2 cells.

    Resveratrol purchased from MCE. Usage Cited in: Redox Biol. 2022 Jun;52:102310.  [Abstract]

    Resveratrol (RES) (10 mg/kg/day; intraperitoneally injected every day for 5 weeks) administration recoveres DOX-reduced expression of SIRT1 in hearts of Sirt1flox/flox mice.

    Resveratrol purchased from MCE. Usage Cited in: Redox Biol. 2022 Jun;52:102310.  [Abstract]

    Primary cardiomyocytes are transfected with NC-siRNA or Sesn2-siRNA for 24 h, and then treated with DOX (1 μM) in the presence or absence of Resveratrol (RES) (20 μM) for 24 h. The protein expression of SIRT1, SESN2, P-AMPKα, AMPKα and cleaved caspase-3 was detected by western blot analysis with densitometric quantification of each group.

    Resveratrol purchased from MCE. Usage Cited in: PLoS Biol. 2022 Jun 30;20(6):e3001682.  [Abstract]

    Immunostaining and brightfield of embryos either untreated or treated with solvent or with Resveratrol (1 μM).

    Resveratrol purchased from MCE. Usage Cited in: Biomed Pharmacother. 2022 Jun;150:113071.

    EX527 antagonizes the protective effect of NRH on Kanamycin-induced hair-cell loss by inhibition of SIRT1, while Resveratrol (RSV; 10 μM) alleviates hair-cell damage caused by EX527.

    Resveratrol purchased from MCE. Usage Cited in: Cells. 2022 Jul 29;11(15):2331.

    The depletion of HSF1 significantly decreased the reactivation efficiencies of Resveratrol.

    Resveratrol purchased from MCE. Usage Cited in: Cell Prolif. 2021 Mar;54(3):e12991.  [Abstract]

    Representative immunoblots of Ac p53 K381, total p53, progerin, Lamin A/C and Lamin B1 of primary HSECs on Day 2 in four groups (CTR, H2O2, H2O2 + Resveratrol, Resveratrol (1 μM; 2 days)).

    Resveratrol purchased from MCE. Usage Cited in: Cell Death Dis. 2021 Nov 29;12(12):1115.  [Abstract]

    Western blot and quantification for MICU3 in C2C12 cells treated with d-gal and Resveratrol (50 μM).

    Resveratrol purchased from MCE. Usage Cited in: Free Radic Biol Med. 2021 Nov 20;176:228-240.  [Abstract]

    Representative images of Rhodamine and DHE of treated BMSCs after indicated treatment.

    Resveratrol purchased from MCE. Usage Cited in: Free Radic Biol Med. 2021 Nov 20;176:228-240.  [Abstract]

    The expression levels of SIRT3, RUNX2, OCN in BMSCs after indicated treatment are analyzed by western blot.

    Resveratrol purchased from MCE. Usage Cited in: ACS Infect Dis. 2021 Apr 9;7(4):777-789.  [Abstract]

    Effects of Resveratrol on meningitic E. coli-induced ERK1/2 activation as well as VEGFA upregulation in hBMECs. By pretreatment with Resveratrol, the phosphorylation of ERK1/2 induced by meningitic E. coli in hBMECs is significantly reduced. Similarly, the upregulation of VEGFA also decreased considerably in a dose-dependent manner in resveratrol-treated hBMECs.

    Resveratrol purchased from MCE. Usage Cited in: Acta Pharmacol Sin. 2021 Feb;42(2):242-251.  [Abstract]

    Resveratrol (50 mg/kg; i.p.; for 2 weeks) has no effect on body weight and kidney index in mice, but it significantly reduces FBG, BUN, and CR.

    Resveratrol purchased from MCE. Usage Cited in: Acta Pharmacol Sin. 2021 Feb;42(2):242-251.  [Abstract]

    Western blotting demonstrates that Resveratrol (50 mg/kg; i.p.; for 2 weeks) increases the expression of E-Ca and ZO-1 and decreases the expression of α-SMA, vimentin, snail, and twist.

    Resveratrol purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847.  [Abstract]

    HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM Vitamin E, and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.

    Resveratrol purchased from MCE. Usage Cited in: J Agric Food Chem. 2017 Jun 7;65(22):4384-4394.  [Abstract]

    Resveratrol activates the HSF1 signaling pathway. J-Lat A2 cells are treated with various concentrations of Resveratrol or Carfilzomib (50 nM) for 48 h. Then the cells are lysed and Ser320 phosphorylated HSF1 and total HSF1 are detected by Western blot with corresponding antibodies.

    Resveratrol purchased from MCE. Usage Cited in: Chinese Journal of Cell Biology. 2015, 37(11):1522-1527.

    Effect of Resveratrol on SIRT1 expression in HK-2 cells.

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    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

    IC50 & Target[1]

    Adenylyl cyclase

    0.8 nM (IC50)

    IKKβ

    1 μM (IC50)

    DNA polymerase α

    3.3 μM (IC50)

    DNA polymerase δ

    5 μM (IC50)

    Autophagy

     

    Mitophagy

     

    Sirtuin

     

    体外研究
    (In Vitro)

    Resveratrol (trans-Resveratrol; SRT501) 是在多种植物来源中发现的众多多酚化合物之一 在绝大多数情况下，Resveratrol 在微摩尔范围内显示出抑制/激活作用，这在药理学上可能是可以实现的，尽管目标在还报道了纳摩尔范围[1]。
    将 MCF-7 细胞接种在添加了 5% FBS 且 Resveratrol 浓度不断增加的 DME-F12 培养基中。对照细胞仅用相同体积的载体 (0.1% 乙醇) 处理。Resveratrol 以剂量依赖性方式抑制 MCF-7 细胞的生长。添加 10 μM Resveratrol 导致 6 天后 82% 的 MCF-7 细胞生长抑制，而在 1 μM 时，仅观察到 10% 的抑制。用 10 μM Resveratrol 处理的细胞的倍增时间为 60 小时，而对照细胞每 30 小时倍增一次。台盼蓝排斥试验表明，在 10 μM 或更低的浓度下，Resveratrol 不会影响细胞活力 (90% 的活细胞)，而在 100 μM 的浓度下，Resveratrol 处理 6 天后只有 50% 的细胞存活。此外，根据 ApoAlert Annexin V 细胞凋亡试剂盒的测定，MCF-7 细胞在与浓度为 10 μM 的 Resveratrol 孵育后不会发生细胞凋亡[2]。
    Resveratrol 通过上调内皮一氧化氮合酶 (eNOS) 的表达、刺激 eNOS 酶活性和阻止 eNOS 解偶联来增加内皮细胞中一氧化氮 (NO) 的产生[7]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Resveratrol 相关抗体:
    体内研究
    (In Vivo)

    Resveratrol (trans-Resveratrol；SRT501) 以 50 mg/kg (195.5±124.8 mm3；P<0.05) 或 100 mg/kg 处理后，与载体处理动物 (315±94 mm3) 相比，平均肿瘤体积减小(81.7±70.5 mm3；P<0.001)。肿瘤体积与肿瘤质量之间存在良好的相关性[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    228.24

    Formula

    C14H12O3
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    白藜芦醇；虎杖甙元；茋三酚；芪三酚
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 100 mg/mL (438.14 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    Ethanol 中的溶解度 : 50 mg/mL (219.07 mM; 超声助溶)

    H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 4.3814 mL 21.9068 mL 43.8135 mL
    5 mM 0.8763 mL 4.3814 mL 8.7627 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    请根据您的 实验动物和给药方式 选择适当的溶解方案。

    以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
    以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 方案 一

      请依序添加每种溶剂： 10% EtOH    40% PEG300    5% Tween-80    45% Saline

      Solubility: 5 mg/mL (21.91 mM); 澄清溶液; 超声助溶

      此方案可获得 5 mg/mL的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 50.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

      生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
    • 方案 二

      请依序添加每种溶剂： 10% EtOH    90% (20% SBE-β-CD in Saline)

      Solubility: 5 mg/mL (21.91 mM); 澄清溶液; 超声助溶

      此方案可获得 5 mg/mL的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 50.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

      20% SBE-β-CD in Saline 的配制（4°C，储存一周）：2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： 50% PEG300    50% Saline

      Solubility: 12.5 mg/mL (54.77 mM); 悬浊液; 超声助溶

    • 方案 二

      请依序添加每种溶剂： 0.5% CMC-Na/saline water

      Solubility: 16.67 mg/mL (73.04 mM); 悬浊液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    请输入您的动物体内配方组成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
    方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
    计算结果
    工作液所需浓度 : mg/mL
    储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
    您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
    动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
    连续给药周期超过半月以上，请谨慎选择该方案。
    请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
    纯度 & 产品资料

    纯度: 99.94%

    COA (283 KB) HNMR (247 KB) RP-HPLC (253 KB) LCMS (107 KB) 元素分析报告 (206 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [2]

    To determine the effect of Resveratrol on cell growth, MCF-7 cells are plated in 6-well plates at 105 cells per well in 2 mL of DME-F12 medium supplemented with 5% FBS in the presence or absence of increasing concentrations of Resveratrol. The cell number is measured every 2 days till day 6 with a hemocytometer after detaching the cells with trypsin-EDTA[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [3]

    Mice[3]
    Female BALB/c (nu/nu) mice, 6 weeks old, are used. PA-1 cells (1×107 in 200 μL PBS) are injected s.c. on the right hind flank. Tumor volume (length×width×depth×0.52) is measured three times a week. After 10 days of implantation, two groups (n=10) are given Resveratrol (dissolved in 5% ethanol and 25% polyethyleneglycol 400 in distilled water) i.p. at a daily dose of 50 or 100 mg/kg body weight for consecutive 4 weeks, whereas the other group receive the vehicle only. Body weights are recorded everyday. Animals are given bromodeoxyuridine (BrdUrd; 10 mg/kg body weight, i.p.) 2 h before sacrifice. Xenograft tumors are weighed and frozen in liquid nitrogen or fixed in 10% formalin and embedded in paraffin. The BrdUrd-labeled cells in paraffin-embedded tissues are detected employing a monoclonal anti-BrdUrd antibody.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Resveratrol 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 4.3814 mL 21.9068 mL 43.8135 mL 109.5338 mL
    5 mM 0.8763 mL 4.3814 mL 8.7627 mL 21.9068 mL
    10 mM 0.4381 mL 2.1907 mL 4.3814 mL 10.9534 mL
    15 mM 0.2921 mL 1.4605 mL 2.9209 mL 7.3023 mL
    20 mM 0.2191 mL 1.0953 mL 2.1907 mL 5.4767 mL
    25 mM 0.1753 mL 0.8763 mL 1.7525 mL 4.3814 mL
    30 mM 0.1460 mL 0.7302 mL 1.4605 mL 3.6511 mL
    40 mM 0.1095 mL 0.5477 mL 1.0953 mL 2.7383 mL
    50 mM 0.0876 mL 0.4381 mL 0.8763 mL 2.1907 mL
    60 mM 0.0730 mL 0.3651 mL 0.7302 mL 1.8256 mL
    80 mM 0.0548 mL 0.2738 mL 0.5477 mL 1.3692 mL
    100 mM 0.0438 mL 0.2191 mL 0.4381 mL 1.0953 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Resveratrol501-36-0trans-Resveratrol SRT501白藜芦醇虎杖甙元茋三酚芪三酚SRT501SRT 501SRT-501IKKAutophagyMitophagySirtuinApoptosisBacterialFungalAntibioticKeap1-Nrf2IκB kinaseI kappa B kinase Mitochondrial AutophagyInhibitorinhibitorinhibit

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